Novel 3-[4-(diethylamino)phenyl]-4-substituted-1-ylsulfonyl) sydnones: Synthesis, characterization and antimicrobial studies
Shahrukh T. Asundaria, Nikul S. Patel and Keshav C. Patel
Org. Commun. (2010), 3:2 ; 30-38
Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat. 395007 Gujarat. India
Abstract: Ten novel 3-[4-(diethylamino)phenyl]-4-substituted-1-ylsulfonyl)sydnones (8a-j) have been synthesized. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. Compound 3-[4-(Diethylamino)phenyl]-4-(piperazin-1-ylsulfonyl)sydnone (8b) and 3-[4-(Diethylamino)phenyl]-4-[(4-methylpiperazin-1-yl)sulfonyl]sydnone (8d) exhibited highest activity against all tested microorganisms. Some compounds were found effectively active against tested organisms.
Keywords: Sydnone; sulfonamide; characterization; antimicrobial. |